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IGF-1 Native 1mg research-grade lyophilized polypeptide vial.

IGF-1 | Native Insulin-like Growth Factor 1 Research Data

Name: IGF-1 | Native Insulin-like Growth Factor 1 Research Data - TITANFORGE LABS
Price: 137.00 USD
Availability: InStock

Original price was: $150.00.Current price is: $137.00.

IGF-1 (Insulin-like Growth Factor 1), also known as Somatomedin C, is a 70-amino acid polypeptide ( $C_{331}H_{512}N_{94}O_{101}S_{7}$ ) that serves as the primary mediator of growth hormone (GH) effects. In laboratory research, IGF-1 is investigated for its highly potent anabolic properties, acting as a critical regulator of cellular proliferation, differentiation, and apoptosis. As the “native” form of the protein, it is studied for its natural binding affinity to IGF-binding proteins (IGFBPs), providing a direct look at endogenous growth signaling pathways.

Categories: GROWTH HORMONE RESEARCH PEPTIDES, RESEARCH-GRADE COMPOUNDS Tags: Cellular Proliferation, Growth Factor, IGF-1, Insulin-like Growth Factor, Protein Synthesis, Research Grade., Somatomedin C

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IGF-1: The Science of Endocrine Growth and Cellular Repair

The Biochemistry of IGF-1

The molecular structure of IGF-1 is highly conserved and shares significant structural homology with proinsulin. Produced primarily in the liver following stimulation by Growth Hormone, it circulates in the plasma largely bound to IGFBPs, which regulate its half-life and biological activity. Research focuses on the three disulfide bridges within the IGF-1 molecule, which are essential for its high-affinity binding to the Type 1 IGF Receptor (IGF-1R).

Mechanism of Action: PI3K/Akt and MAPK Signaling

In advanced endocrinology and oncology research, IGF-1 functions through several coordinated cellular pathways:

IGF-1R Activation: The peptide binds to the IGF-1 receptor, a transmembrane tyrosine kinase, triggering autophosphorylation and the recruitment of insulin receptor substrates (IRS).
PI3K/Akt/mTOR Pathway: Research focuses on this cascade as the primary driver of protein synthesis and cellular hypertrophy. Activation of mTOR leads to increased mRNA translation and muscle fiber maturation.
MAPK/ERK Pathway: IGF-1 is studied for its role in stimulating the mitogen-activated protein kinase pathway, which governs cell division and DNA synthesis.
Inhibition of Apoptosis: The peptide is investigated for its ability to downregulate pro-apoptotic factors, thereby enhancing cell survival under conditions of metabolic or mechanical stress.

Primary Research Applications

Skeletal Muscle Hypertrophy: Analyzing the rate of myoblast proliferation and the fusion of satellite cells into existing muscle fibers.
Bone Density and Growth: Investigating the impact of IGF-1 signaling on osteoblast activity and longitudinal bone growth in developmental models.
Neurotrophic Research: Studying the role of IGF-1 in promoting neuronal survival, axonal growth, and myelin sheath maintenance.
Metabolic Syndrome Models: Observing the peptide’s insulin-mimetic effects on glucose uptake and lipid metabolism in peripheral tissues.

4. Technical Specifications (E-E-A-T Data)

Feature	Scientific Specification
Amino Acid Count	70 Amino Acids
Molecular Formula	$C_{331}H_{512}N_{94}O_{101}S_{7}$
Molecular Weight	7649.0 g/mol
CAS Number	67763-96-6
Purity Grade	$\geq$ 98% (HPLC & Mass Spec Verified)
Structure	Polypeptide with 3 Internal Disulfide Bonds
Solubility	Soluble in Water or 10mM HCl

5. Product FAQ

Q: What is the difference between Native IGF-1 and IGF-1 LR3 in research?

A: Native IGF-1 has a short half-life (approx. 10–20 minutes) due to its high affinity for binding proteins. IGF-1 LR3 is a modified analog with a much lower affinity for these proteins, resulting in a significantly extended half-life of 20+ hours for long-term study protocols.

Q: Why is IGF-1 studied in relation to Growth Hormone (GH)?

A: GH stimulates the liver to produce IGF-1. While GH has its own metabolic effects, the majority of the “anabolic” or growth-promoting effects traditionally attributed to GH are actually executed by IGF-1 at the cellular level.