-8%
Hexarelin 2mg research-grade GHRP hexapeptide lyophilized vial.

Hexarelin | Advanced GHRP & Growth Hormone Research Compound

Original price was: $75.00.Current price is: $69.00.

Hexarelin is a potent synthetic hexapeptide ($His-D-Trp-Ala-Trp-D-Phe-Lys-NH_2$) belonging to the growth hormone-releasing peptide (GHRP) family. Distinguished as one of the most powerful secretagogues in its class, Hexarelin is investigated for its ability to stimulate the pulsatile release of endogenous growth hormone by mimicking ghrelin. Beyond its endocrine effects, Hexarelin is a primary subject in cardiovascular research due to its unique interaction with the CD36 receptor, which is studied for its potential to protect myocardial tissue.

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Hexarelin: The Science of GHS-R1a Activation and Cardiac Resilience

The Biochemistry of Hexarelin

The structure of Hexarelin is a chemically stable analog of GHRP-6, modified to provide a more robust and predictable hormonal response. It functions as a selective agonist of the Growth Hormone Secretagogue Receptor (GHS-R1a) located in the anterior pituitary and hypothalamus. Its hexapeptide sequence allows it to resist rapid enzymatic degradation, facilitating a sustained signaling window for research into somatotropic axis modulation.

Mechanism of Action: Pituitary Stimulation and CD36 Engagement

In advanced endocrinology and cardiology research, Hexarelin functions through several coordinated physiological pathways:

  • Direct Pituitary Stimulation: The peptide binds to the GHS-R1a receptor, triggering a secondary messenger cascade that leads to the rapid, pulsatile secretion of Growth Hormone (GH).

  • Inhibition of Somatostatin: Research focuses on the peptide’s capacity to antagonize somatostatin, the hormone responsible for inhibiting GH release, thereby maximizing the somatotropic output.

  • CD36 Receptor Agonism: Unique among GHRPs, Hexarelin is a known ligand for the CD36 receptor (scavenger receptor) found in the heart and blood vessels. This interaction is investigated for its role in modulating lipid metabolism and inflammatory responses in cardiac tissue.

  • Cardioprotective Signaling: Research models suggest Hexarelin can improve left ventricular function and reduce the death of cardiomyocytes (apoptosis) following ischemic stress or pressure overload.

Primary Research Applications

  • Growth Hormone Deficiency Modeling: Analyzing the sensitivity and responsiveness of the pituitary gland to synthetic secretagogues.

  • Cardiovascular Integrity Research: Investigating the preservation of cardiac function in models of myocardial infarction and heart failure.

  • Skeletal Muscle Homeostasis: Studying the indirect effects of GH/IGF-1 upregulation on muscle fiber hypertrophy and systemic nitrogen retention.

  • Bone Density Studies: Observing the impact of enhanced growth hormone signaling on osteoblast activity and mineral density.

4. Technical Specifications (E-E-A-T Data)

Feature Scientific Specification
Peptide Sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular Formula $C_{47}H_{58}N_{12}O_{6}$
Molecular Weight 887.04 g/mol
CAS Number 140703-51-1
Purity Grade $\geq$99% (HPLC & Mass Spec Verified)
Physical State Lyophilized White Powder
Solubility Soluble in Water and Saline

5. Product FAQ 

Q: How does Hexarelin differ from GHRP-2 or GHRP-6?

A: Research indicates that Hexarelin is often more potent in its GH-releasing capacity than GHRP-6. Furthermore, it possesses a unique affinity for the CD36 receptor, which makes it a specific focus for cardiovascular research that other GHRPs do not typically address.

Q: Does Hexarelin affect appetite like ghrelin?

A: While it mimics ghrelin at the GHS-R1a receptor, research shows that Hexarelin generally has a much lower impact on appetite stimulation compared to GHRP-6 or GHRP-2, allowing researchers to study growth hormone release with fewer metabolic confounding variables.

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Hexarelin 2mg research-grade GHRP hexapeptide lyophilized vial.
Hexarelin | Advanced GHRP & Growth Hormone Research Compound