CJC-1295 Without DAC: The Gold Standard for Pulsatile GH Research

What is CJC-1295 Without DAC (Mod GRF 1-29)?

CJC-1295 Without DAC is a synthetic peptide consisting of 29 amino acids. It is a modified version of the naturally occurring GHRH (1-29) sequence. By substituting four specific amino acids, scientists have created a version that is significantly more resistant to enzymatic degradation while maintaining a natural half-life. Unlike its counterpart (CJC-1295 with DAC), this version does not bind to albumin, allowing for precise, controlled bursts of Growth Hormone (GH).

 

Mechanism of Action: How it Works

In a laboratory setting, CJC-1295 Without DAC acts as a selective agonist of the GHRH receptors in the anterior pituitary gland.

 

• GHRH Emulation: It mimics the signaling of the hypothalamus to trigger the production of endogenous GH.

   

• Pulsatile Secretion: By avoiding the “Drug Affinity Complex,” it ensures that GH levels return to baseline between pulses, preserving the sensitivity of the pituitary-somatotropic axis.

• Synergy with GHRPs: It is frequently studied alongside GHRP-2 or Ipamorelin to observe synergistic effects on IGF-1 elevation.

   

Key Research Applications

1. Metabolic Regulation: Investigating lipid metabolism and adipose tissue reduction.

    

2. Tissue Repair: Observing the rate of cellular regeneration and collagen synthesis.

3. Muscle Hypertrophy: Analyzing the correlation between GH pulses and lean muscle mass preservation.

4. Deep Sleep Studies: Studying the impact of increased GH on slow-wave sleep cycles.

---

4. Technical Specifications (E-E-A-T Data)

Feature	Detail
Molecular Formula	$C_{152}H_{252}N_{44}O_{42}$
Molecular Weight	3367.9 g/mol
CAS Number	448944-47-6
Purity	$\geq$98% (HPLC Tested)
Appearance	White Lyophilized Powder
Storage	Stable at Room Temp (90 days); -20°C recommended long-term.

---

5. Product FAQ

Q: What is the difference between CJC-1295 with DAC and without DAC? A: CJC-1295 with DAC has a half-life of 6–8 days due to its albumin-binding complex. CJC-1295 Without DAC (Mod GRF 1-29) has a 30-minute half-life, making it ideal for researchers wanting to mimic natural, pulsatile GH release.

 

Q: How should CJC-1295 Without DAC be stored? A: For maximum stability, store the lyophilized powder in a freezer at -20°C. Once reconstituted, it should be kept refrigerated between 2°C and 8°C and used within 14–21 days.