GW-501516 (Cardarine) | PPAR$\delta$ Receptor
$77.00
GW-501516, also known as Cardarine, is a high-affinity Peroxisome Proliferator-Activated Receptor delta (PPAR$\delta$) agonist. Initially developed to investigate metabolic and cardiovascular health, GW-501516 is widely utilized in laboratory research to study the regulation of fatty acid metabolism, glucose uptake in skeletal muscle, and the enhancement of physical endurance. By shifting the primary energy source from glucose to lipids, it provides a unique model for researching metabolic efficiency and obesity countermeasures
GW-501516: The Science of PPARδ Signaling
The Biochemistry of GW-501516
GW-501516 is a metabolic modulator that functions as a selective agonist for the PPAR$\delta$ receptor. These receptors are found predominantly in tissues with high energy demands, such as skeletal muscle and the liver. Activation of PPAR$\delta$ by GW-501516 triggers the transcription of genes involved in energy expenditure and lipid catabolism.
Mechanism of Action: Metabolic Reprogramming
In advanced metabolic and exercise physiology research, GW-501516 functions through several coordinated physiological pathways:
-
Upregulation of Fatty Acid Oxidation: The compound stimulates the expression of genes like CPT1, which facilitates the transport of fatty acids into the mitochondria for beta-oxidation.
-
Glucose-to-Lipid Fuel Shift: Research focuses on the ability to “switch” metabolic preference, preserving glycogen stores by increasing the rate of fat burning.
-
Mitochondrial Biogenesis: GW-501516 is investigated for its capacity to increase mitochondrial density in Type I (slow-twitch) muscle fibers, mimicking aerobic endurance training adaptations.
-
Lipid Profile Stabilization: Studies observe that PPAR$\delta$ activation can improve HDL levels and reduce triglycerides by modulating VLDL production in the liver.
Primary Research Applications
-
Endurance and Physical Performance: Analyzing the extension of time-to-exhaustion and oxygen utilization in laboratory aerobic models.
-
Obesity and Metabolic Syndrome: Investigating the reduction of adipose tissue and the improvement of insulin sensitivity in high-fat diet models.
-
Cardiovascular Health Research: Studying the impact of PPAR$\delta$ signaling on arterial plaque formation and systemic inflammation markers.
-
Muscle Fiber Type Transformation: Observing the potential for shifting muscle fibers from Type II (fast-twitch) to more oxidative Type I configurations.
4. Technical Specifications (E-E-A-T Data)
| Feature | Scientific Specification |
| Chemical Name | {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid |
| Molecular Formula | $C_{21}H_{18}F_{3}NO_{3}S_{2}$ |
| Molecular Weight | 453.50 g/mol |
| CAS Number | 317318-73-0 |
| Purity Grade | $\geq$99% (HPLC Verified) |
| Form | Research Grade Tablets (10mg Standardized) |
| Solubility | Soluble in DMSO and Ethanol |
5. Product FAQ
Q: Is GW-501516 a SARM? A: No. GW-501516 is a PPAR$\delta$ receptor agonist. It does not interact with the androgen receptor and does not influence testosterone levels, making it structurally and functionally distinct from SARMs.
Q: Why is GW-501516 studied for endurance? A: Because it activates pathways that increase mitochondrial density and fat oxidation, it allows researchers to study “exercise mimetic” effects that improve aerobic capacity in laboratory subjects.
Related products
GROWTH HORMONE RESEARCH PEPTIDES
WEIGHT MANAGEMENT & METABOLIC WELLNESS
5-HTP Peptide Precursor Complex | Appetite & Serotonin Research
RESEARCH-GRADE COMPOUNDS
NEUROPEPTIDE RESEARCH COMPOUNDS
PERFORMANCE STACKS
The Ultimate Performance Stack | Peak Physiological Research
