AICAR 10mg research-grade tablets (Acadesine) for AMPK activation and metabolic studies.

AICAR (Acadesine) | Advanced AMPK Activator & Metabolic

Name: AICAR (Acadesine) | Advanced AMPK Activator & Metabolic - TITANFORGE LABS
Price: 82.00 USD
Availability: InStock

$82.00

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as Acadesine, is a potent activator of AMP-activated protein kinase (AMPK). In laboratory research, AICAR functions as a cell-permeable mimetic of adenosine monophosphate (AMP), capable of stimulating metabolic pathways typically activated during physical exertion. It is a primary subject for investigating cellular energy homeostasis, increased fatty acid oxidation, and glucose transport in skeletal muscle without the requirement for mechanical contraction.

Category: SARMS Tags: Acadesine, AICAR, AMPK Activator, Exercise Mimetic, Glucose Uptake, Metabolic Research, Research Grade.

Description

AICAR: The Science of AMPK Activation and Metabolic Signaling

The Biochemistry of AICAR

AICAR is an intermediate in the generation of inosine monophosphate. Once inside the cell, it is phosphorylated into ZMP (an AMP analogue), which directly binds to the $\gamma$ -subunit of AMPK. This binding triggers the master metabolic switch, signaling the cell to shift from energy-consuming processes (anabolism) to energy-producing processes (catabolism).

Mechanism of Action: Exercise Mimetic Pathways

In advanced metabolic and cardiovascular research, AICAR functions through several coordinated physiological pathways:

AMPK Phosphorylation: By mimicking a high AMP:ATP ratio, AICAR activates AMPK, which subsequently upregulates PGC-1$\alpha$, a key regulator of mitochondrial biogenesis.
GLUT4 Translocation: Research focuses on the compound’s ability to stimulate the movement of glucose transporter type 4 (GLUT4) to the cell membrane, enhancing glucose uptake in insulin-resistant models.
Fatty Acid Oxidation: AICAR is investigated for its role in inhibiting Acetyl-CoA carboxylase (ACC), thereby reducing malonyl-CoA levels and increasing the transport of fatty acids into the mitochondria for energy production.
Vasodilation and Ischemic Protection: Studies observe that AICAR may enhance the release of adenosine, providing a protective effect against ischemic injury by improving blood flow and reducing inflammatory markers.

Primary Research Applications

Metabolic Syndrome and Type 2 Diabetes: Analyzing the restoration of glucose homeostasis and insulin sensitivity in metabolic dysfunction models.
Endurance and Mitochondrial Research: Investigating the impact of “exercise-in-a-pill” mimetics on mitochondrial density and aerobic capacity in sedentary laboratory subjects.
Cardiovascular Protection: Studying the peptide’s ability to mitigate reperfusion injury and support cardiac function during periods of low oxygen.
Autophagy and Longevity: Observing how AMPK activation influences cellular “cleanup” processes (autophagy) and systemic aging markers.

4. Technical Specifications (E-E-A-T Data)

Feature	Scientific Specification
Chemical Name	5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
Molecular Formula	$C_{10}H_{14}N_{4}O_{5}$
Molecular Weight	258.23 g/mol
CAS Number	2627-69-2
Purity Grade	$\geq$ 99% (HPLC Verified)
Form	Research Grade Tablets (10mg Standardized)
Solubility	Soluble in Water and DMSO

5. Product FAQ

Q: Is AICAR a SARM or a hormone?

A: No. AICAR is an AMPK activator and a nucleotide intermediate. It does not interact with androgen receptors and has no hormonal activity. Its primary influence is on cellular energy metabolism.

Q: Why is AICAR called an “exercise mimetic”?

A: It is researched for its ability to activate the same metabolic pathways (specifically AMPK) that are triggered by high-intensity aerobic exercise, allowing researchers to study the benefits of exercise at a cellular level without physical activity.